Effect of angiotensin II on body fluid volume of the freshwater oligochaete

Angiotensin (Ang) II upregulates body fluid volume in vertebrates; however, it produces varying effects in invertebrates. Ang II upregulates body fluid volume in clam worms and slugs organisms), but downregulates it in downregulating effect of Ang II in leeches is caused by their blood effects of Ang I and Ang II on body fluid volume in the freshwater sludge worm, (Annelida, Oligochaeta, Tubificidae) exposed to Ang I or Ang II dissolved in artificial pond water. worms in a timeand dose-dependent manner, whereas Ang I had no effect. To determine if the Ang II receptors were involved in this Ang II II receptor inhibitor, saralasin. Saralasin inhibited Ang II saralasin, [Sar1, Val5, Ala8]-Ang II, exhibited a gr human-type saralasin, [Sar1, Ala8]vertebrates and some other invertebrates, reduces the body fluid volume of receptor. The findings will help to evolutionarily evaluate functions of the renin mammals.